Fig. 1

Algorithm for mucopolysaccharidosis type I (MPS I)-positive newborn screening, modified from [38]. DBS dried blood spots, ERT enzyme replacement therapy, GAG glycosaminoglycan, HSCT hematopoietic stem cell transplantation, IDUA alpha-l-iduronidase, NBS newborn screening, uGAG urinary glycosaminoglycan, VUS variant of unknown significance