Table 1 Respiratory disorders in MPS patients: a review of the literature
| Â | No. of patients | MPS type (n) | Respiratory disorders |
|---|---|---|---|
Kiely, 2017 [3] | 55 | MPS I | RI (54.5%) Snoring (85.5%) OSA (32.7%) Laryngomalacia (9.1%) |
Cohen, 2017 [34] | 43 | MPS III | RI (34.88%) OSA (30.23%) T&A (34.88%) |
Chiong, 2017 [35] | 23 | MPS II | UAO (39%) RI (78.3%) OSA (39%) T&A (39%) |
Lin, 2014 [36] | 35 | MPS I (1) MPS II (12) MPS III (4) MPS IV (16) MPS VI (6) | T&A (96%) OSA (71%) Laryngomalacia (38%) |
Muhlebach, 2013 [37] | 31 | MPS I (9) MPS II (19) MPS III (1) MPS IV (1) MPS VI (1) | T&A (72%) Bronchomalacia (46%) Laryngomalacia (31%) |
Wold, 2010 [9] | 9 | MPS I (5) MPS II (3) MPS VI (1) | UAO (44.4%) |
Yeung, 2009 [29] | 27 | MPS IH (8) MPS IH/S (3) MPS II (5) MPS III B (1) MPS VI (1) | UAO (70%) RI (47%) |
Bredenkamp, 1992 [38] | 45 | MPS IH (13) MPS II (7) MPS III (12) MPS IV (6) MPS VI (5) MPS VII (2) | UAO (38%) |
Semenza, 1988 [17] | 21 | MPS IH (4) MPS IH/S (3) MPS II (3) MPS IV (6) MPS VI (3) MPS VII (4) | UAO (50–90%) T&A (67%) Supraglottic narrowing (92%) OSA (89%) |