Fig. 1

Cardiac and systemic hallmarks/flags (red, orange, yellow) for the clinical diagnosis of MPS in children. Definite diagnosis: combination of cardiac + systemic red flags; probable diagnosis: combination of cardiac + systemic orange flags; possible diagnosis: combination of cardiac + systemic yellow flags. This classification is based on expert points of view and prevalence of defects. To date, no data are available on sensitivity and specificity of single and composed clinical hallmarks of the disease. ECG electrocardiography, dyspl dysplasia, Resp Infect respiratory infections