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Table 2 Betalactam provocation test

From: SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children

Symptoms Procedures
Immediate reactions with negative skin tests Graded challenge
1/10 TD (1/100 TD or 1/1000 TD when risk is high, e.g. severe asthma)
then 2/10 TD and 7/10 TD every 30 min
2 h observation after last dose
Delayed reactions Graded challenge as DPT for immediate reactions, or a full-dose challenge. The daily therapeutic dose is given at home for a minimum of 5 days up to 7 days.
Positive skin tests Anaphylaxis Desensitization
  1. TD therapeutic dose
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