Table 3 Methods of drug provocation test for NBLA

Mild urticaria or mild skin reactions

Full-dose challenge

Mild/moderate urticaria or other skin reactions Negative skin tests

Graded challenge

(1/100 TD or 1/1000 TD when risk is high, e.g. severe asthma)

1/10 TD

2/10 TD

7/10 TD

1 h observation after each dose

Positive skin tests Anaphylaxis

Desensitization