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Table 3 Methods of drug provocation test for NBLA

From: SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children

Symptoms Procedures
Mild urticaria or mild skin reactions Full-dose challenge
Mild/moderate urticaria or other skin reactions Negative skin tests Graded challenge
(1/100 TD or 1/1000 TD when risk is high, e.g. severe asthma)
1/10 TD
2/10 TD
7/10 TD
1 h observation after each dose
Positive skin tests Anaphylaxis Desensitization
  1. TD, therapeutic dose
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