No. (%) 266 | PFS | p | OS | ||||||
---|---|---|---|---|---|---|---|---|---|
Univariate | p | Multivariate | Univariate | Multivariate | |||||
HR (95% CI) | HR (95% CI) | HR (95% CI) | p | HR (95% CI) | p | ||||
Major symptoms | |||||||||
None | 68 (25.4) | 1 | < 0.001 | 1 | < 0.001 | 1 | < 0.001 | 1 | < 0.001 |
Dyspnea ± Organ dysfunction | 12 (4.5) | 3.5 (1.2–10.2) | 3.1 (1.1–9.3) | 5.9 (0.8–41.6) | 4.6 (0.6–33.2) | ||||
Hepatomegaly ± Organ dysfunction | 146 (54.5) | 2.4 (1.2–4.7) | 2.2 (1.1–4.3) | 5.3 (1.2–22.6) | 4.6 (1.1–19.8) | ||||
Hepatomegaly + Dyspnea (± Organ dysfunction) | 40 (14.9) | 5.5 (2.6–11.7) | 5.5 (2.6–11.8) | 24.4 (5.7–104.4) | 24.1 (5.6–103.4) | ||||
Treatment era | |||||||||
1979–1984 | 25 (9.4) | 1 | 0.202# | 1 | 0.355# | 1 | 0.041# | 1 | 0.049# |
1985–1999 | 116 (43.6) | 1.3 (0.6–2.7) | 1.4 (0.7–3.0) | 1 (0.4–2.4) | 1.2 (0.5–2.8) | ||||
2000–2013 | 125 (47.0) | 0.8 (0.4–1.8) | 0.9 (0.4–2.0) | 0.5 (0.2–1.3) | 0.5 (0.2–1.3) | ||||
Gender | |||||||||
Male | 154 (57.9) | 1 | 0.209 | 1 | 0.707 | 1 | 0.013 | 1 | 0.091 |
Female | 112 (42.1) | 0.8 (0.5–1.2) | 0.8 (0.5–1.3) | 0.5 (0.2–0.9) | 0.6 (0.3–1.1) | ||||
Age, days | |||||||||
0–29 | 60 (22.6) | 1 | 0.077 | 1 | 0.637 | 1 | 0.011 | 1 | 0.639 |
30–365 | 206 (77.4) | 0.6 (0.4–1.0) | 0.9 (0.5–1.5) | 0.4 (0.2–0.8) | 0.9 (0.4–1.6) | ||||
Abdominal mass | |||||||||
None | 232 (87.2) | 1 | 0.052 | 1 | 0.751 | 1 | 0.006 | 1 | 0.813 |
Yes | 34 (12.8) | 0.5 (0.2–1.1) | 1.2 (0.4–3.6) | 0.1 (0.0–1.0) | 0.7 (0.1–8.4) |