Novel DNA variation of GPR54 gene in familial central precocious puberty

Table 1 Clinical and Homoral features of 25 patients with central precocious puberty

Patient No.	Sex	Initial Clinical Presentation	age	Tanner Stage	Bone age Advance (years)	LH		FSH		EST Level	Testosterone Level
Patient No.	Sex	Initial Clinical Presentation	age	Tanner Stage	Bone age Advance (years)	Basal	After test	Basal	After test
Family A
A-I	F	Thelarche	5y	3	7	0.8	-	3.8	-	32	-
A-II	F	Thelarche	22m	2	4	2.3	9.1	4.2	15	24	-
Family B
B-I	F	Thelarche+Menarche	8 y	4	10.5	2.1	-	2.6	-	36.1	-
B-II	F	Thelarche+Menarche	8 y	4	10.5	2.4	-	3	-	40	-
B-III	F	Thelarche	8.5 y	2	11	1.5	-	4.6	-	24.2	-
Family C
C-I	F	Thelarche	4y	3	5.2	1.2	8.1	3.1	8.4	42	-
C-II	M	Testicular enlargement	7y	2	9	2.1	-	6	-	-	116
Family F
F-I	F	Thelarche	6.2y	2	8.5	1.8	-	4.2	-	36	-
F-II	F	Thelarche	5.3y	2	8	2.6	-	4.1	-	42	-
Family G
G-I	F	Thelarche	6.5y	2	9	2.3	-	6.1	-	26	-
G-II	F	Thelarche	4.2y	2	6.4	4.1	-	5.9	-	32	-
Family H
H-I	F	Thelarche+Menarche	6y	4	10.5	3.2	-	6.1	-	42	-
H-II	F	Thelarche+Menarche	7y	4	11	2.9	-	5.4	-	36	-
Family I
I-I	F	Thelarche	4y	2	6.2	1.8	-	3.2	-	26	-
I-II	F	Thelarche	5y	2	7.1	2.1	-	2.61	-	30	-
Family K
K-I	F	Thelarche	7y	2	9.5	2.1	-	6.2	-	22	-
K-II	F	Thelarche	7y	2	10	3.8	-	8.1	-	41	-
Family L
L-I	F	Thelarche	5Y	2	8.1	1.2	6.9	3.1	17.9	46	-
L-II	F	Thelarche	6.5Y	3	9.5	2.8	8.1	4.8	15.3	31	-
Family M
M-I	F	Thelarche	6	2	8	2.3	-	4.1	-	26	-
M-II	F	Thelarche	5	3	7.5	1.4	-	3.6	-	28	-
Family N
N-I	F	Thelarche	7	3	9.5	3.6	-	4.1	-	41	-
N-II	F	Thelarche	7	3	8.7	2.8	-	3.9	-	31	-
Family O
O-I	F	Thelarche	7	2	9.2	1.4	-	3.1	-	28	-
O-II	F	Thelarche	5.5	3	7	1.2	-	4.9	-	32	-

ISSN: 1824-7288