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Table 1 Clinical and Homoral features of 25 patients with central precocious puberty

From: Novel DNA variation of GPR54 gene in familial central precocious puberty

Patient No. Sex Initial Clinical Presentation age Tanner Stage Bone age
Advance (years)
LH FSH EST Level Testosterone Level
Basal After test Basal After test   
Family A
 A-I F Thelarche 5y 3 7 0.8 - 3.8 - 32 -
 A-II F Thelarche 22m 2 4 2.3 9.1 4.2 15 24 -
Family B
 B-I F Thelarche+Menarche 8 y 4 10.5 2.1 - 2.6 - 36.1 -
 B-II F Thelarche+Menarche 8 y 4 10.5 2.4 - 3 - 40 -
 B-III F Thelarche 8.5 y 2 11 1.5 - 4.6 - 24.2 -
Family C
 C-I F Thelarche 4y 3 5.2 1.2 8.1 3.1 8.4 42 -
 C-II M Testicular enlargement 7y 2 9 2.1 - 6 - - 116
Family F
 F-I F Thelarche 6.2y 2 8.5 1.8 - 4.2 - 36 -
 F-II F Thelarche 5.3y 2 8 2.6 - 4.1 - 42 -
Family G
 G-I F Thelarche 6.5y 2 9 2.3 - 6.1 - 26 -
 G-II F Thelarche 4.2y 2 6.4 4.1 - 5.9 - 32 -
Family H
 H-I F Thelarche+Menarche 6y 4 10.5 3.2 - 6.1 - 42 -
 H-II F Thelarche+Menarche 7y 4 11 2.9 - 5.4 - 36 -
Family I
 I-I F Thelarche 4y 2 6.2 1.8 - 3.2 - 26 -
 I-II F Thelarche 5y 2 7.1 2.1 - 2.61 - 30 -
Family K
 K-I F Thelarche 7y 2 9.5 2.1 - 6.2 - 22 -
 K-II F Thelarche 7y 2 10 3.8 - 8.1 - 41 -
Family L
 L-I F Thelarche 5Y 2 8.1 1.2 6.9 3.1 17.9 46 -
 L-II F Thelarche 6.5Y 3 9.5 2.8 8.1 4.8 15.3 31 -
Family M
 M-I F Thelarche 6 2 8 2.3 - 4.1 - 26 -
 M-II F Thelarche 5 3 7.5 1.4 - 3.6 - 28 -
Family N
 N-I F Thelarche 7 3 9.5 3.6 - 4.1 - 41 -
 N-II F Thelarche 7 3 8.7 2.8 - 3.9 - 31 -
Family O
 O-I F Thelarche 7 2 9.2 1.4 - 3.1 - 28 -
 O-II F Thelarche 5.5 3 7 1.2 - 4.9 - 32 -