Table 1 Patient clinical features and allergy test results before starting omalizumab
From: Omalizumab in children with severe allergic disease: a case series
Patient | Age | Sex | Allergy disease | Comorbidity | Symptoms | SPT and PBP (mm) | Serum IgEs (KU/L) | Total Serum IgE (IU/L) | Maintenance Therapy | First Aid Access | Hospitalizations | ACT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 13 | M | Severe asthma | Allergic rhinitis, Eosinophilic esophagitis | Non-controlled asthma and exacerbations during HDM SLIT | DP = 9, DF = 7, Olea = 5 Milk = 8, Bos d 8 = 6 Bos d 4 = 10, Bos d 5 = 7 PBP = 10 | DP = 100, DF = 82 Olea = 68 Milk = 2.14 --- --- | 1003 | Fluticasone 1000 mcg/die LABA 100 mcg/die LTRA 10 mg/die | 3 | 3 | 8 |
2 | 15 | M | Severe asthma | Allergic rhinitis, Chronic rhinosinusitis | Noncontrolled asthma and exacerbations during HDM SLIT | DP = 5, DF = 6 Pellitory = 5 | DP = 100, DF = 100 Pellitory = 12 | 372 | Fluticasone 1000 mcg/die LABA 100 mcg/die LTRA 10 mg/die | 3 | 3 | 14 |
3 | 10 | M | Moderate-severe asthma Severe Cow’s milk allergy | / | Anaphylactic reaction with traces cow’s milk | DP = 5, DF = 4 Pellitory = 5, Cat = 4 Milk = 16, Bos d 4 = 13, Bos d 5 = 11, Bos d 8 = 12 | DP = 23.4, DF = 17.1 Pellitory =20.7, Cat = 9.51, Milk > 100, Bos d 8 = 100, Bos d 4 = 92, Bos d 5 = 38.6 | 668 | Fluticasone 500 mcg/die LABA 100 mcg/die | 2 | 2 | 16 |
4 | 9 | F | Severe asthma | Pnx, Pnm | Non-controlled asthma and frequent exacerbations PNX | DP = 5, DF = 3 | DP = 62.8, DF = 31.3 | 280 | Fluticasone 500 mcg/die LABA 100 mcg/die LTRA 10 mg/die | 5 | 5 | 10 |
5 | 7 | F | Severe Cow’s milk allergy | / | Anaphylaxis after 4 ml of cow’s milk | Milk = 7 Bos d 8 = 7 Bos d 4 = 6 Bos d 5 = 5 | Milk = 20.9 Bos d 8 = 18.1 Bos d 4 = 5.73 Bos d 5 = 3.49 | 68.8 | OIT | 4 | 4 | / |
6 | 14 | M | Moderate-severe asthma Severe cow’s milk allergy | / | Asthma exacerbation after cow’s milk in traces | DP = 4, DF = 3 Cat = 4, Dog = 5 Milk = 8, PBP milk = 11 Bos d 4 = 13.5 mm, Bos d 5 = 8 mm, Bos d 8 = 11 mm | DP = 1.18, DF = 1.12 Cat = 1, Dog 3.21 Milk = 90, Bos d 8 = 62.3 Bos d 4 = 62.5 Bos d 5 = 36.6 | 597 | Fluticasone 1000 mcg/die LABA 100 mcg/die | 6 | 6 | 12 |
7 | 8 | M | Severe cow’s milk allergy | / | Anaphylaxis after cow’s milk in traces | Milk 7 Bos d 8 = 12 Bos d 4 = 6 Bos d 5 = 11 PBP milk = 15 | Milk 25.1 Bos d 8 = 16 Bos d 4 = 5.99 Bos d 5 = 4.24 | 79.9 | OIT | 1 | 1 | / |
8 | 11 | M | Moderate-severe asthma Severe cow’s milk allergy | / | Anaphylaxis after cow’s milk in traces | DP = 4, DF = 5 Pellitory = 5, Cat = 5 Milk = 16, Bos d 8 = 18 Bos d 4 = 11, Bos d 5 = 12 PBP milk = 17 | DP = 17.1, DF = 23.4 Pellitory = 20.7, Cat = 9.51 Milk > 100, Bos d 8 > 100 Bos d 4 = 15.8 Bos d 5 = 9.26 | 972 | Fluticasone 500 mcg/die LABA 100 mcg/die | 4 | 4 | 14 |