Skip to main content

Table 1 Patient clinical features and allergy test results before starting omalizumab

From: Omalizumab in children with severe allergic disease: a case series

Patient Age Sex Allergy disease Comorbidity Symptoms SPT and PBP (mm) Serum IgEs (KU/L) Total Serum IgE (IU/L) Maintenance Therapy First Aid Access Hospitalizations ACT
1 13 M Severe asthma Allergic rhinitis,
Eosinophilic esophagitis
Non-controlled asthma and exacerbations during HDM SLIT DP = 9, DF = 7, Olea = 5
Milk = 8, Bos d 8 = 6
Bos d 4 = 10, Bos d 5 = 7
PBP = 10
DP = 100, DF = 82
Olea = 68
Milk = 2.14
---
---
1003 Fluticasone 1000 mcg/die
LABA 100 mcg/die
LTRA 10 mg/die
3 3 8
2 15 M Severe asthma Allergic rhinitis,
Chronic rhinosinusitis
Noncontrolled asthma and exacerbations during HDM SLIT DP = 5, DF = 6
Pellitory = 5
DP = 100, DF = 100
Pellitory = 12
372 Fluticasone 1000 mcg/die
LABA 100 mcg/die
LTRA 10 mg/die
3 3 14
3 10 M Moderate-severe asthma
Severe Cow’s milk allergy
/ Anaphylactic reaction with traces cow’s milk DP = 5, DF = 4
Pellitory = 5, Cat = 4
Milk = 16, Bos d 4 = 13,
Bos d 5 = 11, Bos d 8 = 12
DP = 23.4, DF = 17.1
Pellitory =20.7,
Cat = 9.51,
Milk > 100,
Bos d 8 = 100,
Bos d 4 = 92,
Bos d 5 = 38.6
668 Fluticasone 500 mcg/die
LABA 100 mcg/die
2 2 16
4 9 F Severe asthma Pnx, Pnm Non-controlled asthma and frequent exacerbations
PNX
DP = 5, DF = 3 DP = 62.8, DF = 31.3 280 Fluticasone 500 mcg/die
LABA 100 mcg/die
LTRA 10 mg/die
5 5 10
5 7 F Severe Cow’s milk allergy / Anaphylaxis after
4 ml of cow’s milk
Milk = 7
Bos d 8 = 7
Bos d 4 = 6
Bos d 5 = 5
Milk = 20.9
Bos d 8 = 18.1
Bos d 4 = 5.73
Bos d 5 = 3.49
68.8 OIT 4 4 /
6 14 M Moderate-severe asthma
Severe cow’s milk allergy
/ Asthma exacerbation after cow’s milk in traces DP = 4, DF = 3
Cat = 4, Dog = 5
Milk = 8, PBP milk = 11
Bos d 4 = 13.5 mm,
Bos d 5 = 8 mm,
Bos d 8 = 11 mm
DP = 1.18, DF = 1.12
Cat = 1, Dog 3.21
Milk = 90,
Bos d 8 = 62.3
Bos d 4 = 62.5
Bos d 5 = 36.6
597 Fluticasone 1000 mcg/die
LABA 100 mcg/die
6 6 12
7 8 M Severe cow’s milk allergy / Anaphylaxis after cow’s milk in traces Milk 7
Bos d 8 = 12
Bos d 4 = 6
Bos d 5 = 11
PBP milk = 15
Milk 25.1
Bos d 8 = 16
Bos d 4 = 5.99
Bos d 5 = 4.24
79.9 OIT 1 1 /
8 11 M Moderate-severe asthma
Severe cow’s milk allergy
/ Anaphylaxis after cow’s milk in traces DP = 4, DF = 5
Pellitory = 5, Cat = 5
Milk = 16, Bos d 8 = 18
Bos d 4 = 11, Bos d 5 = 12
PBP milk = 17
DP = 17.1, DF = 23.4
Pellitory = 20.7,
Cat = 9.51
Milk > 100, Bos d 8 > 100
Bos d 4 = 15.8
Bos d 5 = 9.26
972 Fluticasone 500 mcg/die
LABA 100 mcg/die
4 4 14
  1. Abbreviations: ACT asthma control test, DP Dermatophagoides pteronyssinus, DF Dermatophagoides farinae, HDM house dust mite, IgE immunoglobulin E, LABA long acting beta2agonist, LTRA leukotriene receptor antagonist, OIT oral immunotherapy, PBP prick by prick, Pnm pneumomediastinum, Pnx pneumothorax, SLIT sublingual specific immunotherapy, SPT skin prick test