Fig. 1From: Association of neural tube defects with maternal alterations and genetic polymorphisms in one-carbon metabolic pathwaySimplified overview of one-carbon metabolism pathway. MTHFR, methylene tetrahydrofolate reductase; MTHFD1, methylenetetrahydrofolate dehydrogenase 1; MTR, methionine synthase; MTRR, methionine synthasereductase; RFC1, reduced folate carrier 1; BHMT, betaine-homocysteine methyltransferase; CBS, cystathionine beta synthase;SHMT, serine hydroxymethyltransferase; AdoHcy, S-adenosylhomocysteine; AdoMet, S-adenosylmethionineBack to article page