Fig. 3

Function of B7-H3 on CD4⁺ T cells to induce expression of ROR-γt and IL-17A. Different concentrations of B7-H3 fusion protein (0.6 μg / ml, 3 μg / ml and 15 μg / ml) or human IgG as control group co-cultured with CD4⁺ T cells for 24 h. The expression of transcription factor ROR-γt (a) and IL-17A (b) was detected by real-time PCR and ELISA, respectively. P < 0.05 was considered statistically significant