Base excess and hematocrit predict response to indomethacin in very low birth weight infants with patent ductus arteriosus

Table 2 Pretreatment bedside clinical parameters by treatment outcome

Variable	Responders N = 62 (68%) Mean (SD)	Non-responders N = 29 (32%) Mean (SD)	P value
Capillary blood gas
pH	7.30 (0.04)	7.27 (0.05)	0.02
HCO₃	24.6 (3.5)	20 (2.9)	< 0.001
Base excess	−0.8 (3.2)	−5.7 (3.3)	< 0.001
PCO₂	49 (8)	48 (8)	0.86
Hematocrit	42 (4)	39 (5)	0.001
Na⁺	139 (5)	139 (4.3)	0.95
Fluid intake (mL/kg/d)	122 (16)	133 (22)	0.06
Weight (g)	883 (320)	752 (225)	0.04
UOP (m/kg/h)	3.3 (1)	3.8 (0.9)	0.04
BUN	35 (13)	42 (29)	0.94
Creatinine	0.9 (0.2)	0.9 (0.3)	0.52

SD standard deviation, PCO₂ partial pressure of carbon dioxide, PO₂ partial pressure of oxygen, UOP urine output, BUN blood urea nitrogen

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