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Table 2 Demographic and during MRI characteristic of the patients enrolled into the study, comparing the 3 groups related do the admisnistred dose of melatonine

From: A solution based on melatonin, tryptophan, and vitamin B6 (Melamil Tripto©) for sedation in newborns during brain MRI

Dose (number of neonates) 2 mg (32) 3 mg (72) 4 mg (5) p-value
GA (wk) median (IQR) 31,1 (29,7-30) 31,3 (29,7-36,2) 31,1 (27,9-39,5) 1
BW (g) median (IQR) 1300 (1025-2665) 1530 (1310-2040) 1300 (1030-1300) 0,058
PMA (wk) at MRI median (IQR) 46 (42,3-48,7) 47 (42,9-48,9) 44 (43,7-47,4) 0,69
Weight at MRI (g) median (IQR) 3800 (3190-4600) 4500 (3800-5200) 4600 (3740-5975) 0,017
Time (min) to reach sleeping median (IQR) 25 (15-35) 25 (17-35) 32 (22-50) 0,52
Duration MRI (min) median (IQR) 20 (20-30) 25 (17-35) 31 (26-34) 0,42
HR (bpm) median (IQR) 140 (130-148) 140 (130-145) 142 (132-143) 0,66
SatO2 (%) median (IQR) 98 (97-98) 98 (97-99) 99 (96-99) 0,24
Dose pro Kg (mg/kg) median (DS) 0,52 (± 0,11) 0,64 (± 0,15) 0,85 (± 0,16) < 0,001
  1. GA Gestational Age, BW Birth Weight, PMA Post Menstrual Age, HR Heart Rate, IQR Interquartile Range, DS Deviation Standard