Table 1 Case reports of enteritis and/or gastrointestinal haemorrhage in immunocompetent patients with EBV- LPD
Source, y | Age at diagnosis, y/Sex | Duration between symptom onset to hospital admission | Symptoms; misdiagnose | Duration of haemorrhage, amount of bleeding | Diseased region with haemorrhage | Intestinal pathology | PCR VCA-IgM VCA-IgG EA EBNA EBER | Serum EBV DNA copies/ml | Infected cell | Operation | Drug Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
Wang et al. [6], 2018 | 43y/F† | 2 m | intermittent fever, chill, abdominal pain, diarrhea, hematochezia; NA | 4d, large | multiple aphthous bleeding ulcers scattered from the stoma to about 40 cm away from small intestine | Multiple colonic ulcers | NT + + + + + | 2.55 × 10^6 | T | total colectomy | Mesalazine,Glucocorticoid,antiviral medication |
Xiao et al. [9], 2016 | 14y/M† | 1.75 y | bellyache, diarrhea, fever, hematochezia, gastrointestinal Perforations; IBD | 1 y, large | Intestinal hemorrhea | diffuse heterotypic lymphoid cells infiltration, karyorrhexis and patchy necrosis | NT NT + + + + | NT | T/NK | gastrointestinal perforation repair, intestinal anastomosis | Mesalazine,Prednisone |
Chen et al. [10], 2016* | 29/M†* | over 1y | recurrent diarrhea,abdominal pain, fever,intestinal perforation; CD | NA,large | NA | multiple ulcers in esophagus, stomach, terminal ileum, and the entire colon | NT + NT NT NT + | NT | T | partial intestinal bowel resection,terminal ileum colostomy | Methylprednisolone, mesalazine, anti-TNF, chemotherapy |
Zheng et al. [11], 2015 | 26y/M† | Over 3 m | intermittent fever, diarrhea, hematochezia; UC | More than 1 m, large | multiple colorectal ulcers | Multiple colorectal ulcers | + NT + + + + | 9 × 10^4 | T | right hemicolectomy | antiviral and hormonal therapy |
Na et al. [12], 2013 | 49y/F#@ | 19 m | recurrent hematochezia, small bowel perforation; CD | 10 m, large recurrent hematochezia | small bowel | multiple ulcer scars in the cecum and ascending colon | NT NT NT NT NT NT | 1.75× 10^3 | T | near-total small bowel resection | Prednisolone, infliximab (5 mg/kg) infusion, chemotherapy |
Na et al. [12], 2013 | 50y/M† | 8y | weakness, anorexia, weight loss, loose stools, fever, perforation; intestinal TB and CD | No | No | an ulcer at the terminal ileum ,multiple discrete ulcers scattered from the distal ascending colon to the rectum | NT NT NT NT NT + | 3.45× 10^4 | T | small bowel resection; jejuno-ileostomy | anti-tuberculous, Prednisolone, Mesalamine, chemotherapy |
Abdul-Ghafar et al. [13], 2011 | 45y/M† | 45d | diarrhea, weight loss; UC | 3d, large | extensive ulcerations along the whole colon | multiple ulcerations scattered along the whole colon and ileocecal valve | + NT NT NT NT + | NT | T | total colectomy | oral metronidazole, intra-venous antibiotics |
Karlitz et al. [14],2011 | 30y/M# | 2 m | lower abdominal bloating and loose, bloody, mucoid bowel movements | NA,small | NA | diffuse erythematous and edematous mucosa located contiguously throughout the colon | + NT NT NT NT + | NT | B | ND | supportive care alone |
Our case | 5y/M# | Over 2y | recurrent fever,diarrhea, abdominal pain, Hematochezia, polyuria;CD | 3d,large | a duodenal ulcer and dilatation of duodenal artery | a duodenal ulcer, and the entire colon ulcers | + - - NT NT + | 1.17 × 10 ^ 4 | NA | ND | Prednisolone, Ganciclovir, thalidomide, propranolol |