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Table 1 Demographic data and measured biomarkers in T1DM patients and controls

From: OPG/RANK/RANKL signaling axis in patients with type I diabetes: Associations with parathormone and vitamin D

 T1DM (n = 71)Controls (n = 50)p value
Gender (boys/girls)41/3026/240.580a
age (years)13 (11–16)12 (10–13.2)0.071b
Duration of diabetes (years)5 (4–8)
HbA1c (%)7.5 (6.8–8.2)5.3 (5.1–5.3)< 0.001**b
Glu (mg/dl)203 ± 7386 ± 9< 0.001**c
Ca (mg/dl)9.75 ± 0.389.62 ± 0.360.066c
P (mg/dl)4.39 ± 0.524.42 ± 0.90.862c
Mg (mg/dl)1.92 (1.76–2.04)1.95 (1.8–2.09)0.105b
ALP (U/L)222 ± 110151 ± 82< 0.001**c
PTH (pg/ml)46.75 ± 17.126.56 ± 9.87< 0.001**c
25(OH) D (ng/ml)26.6 (21.8–32.3)54.3 (48.7–60.5)< 0.001**b
SGOT (U/L)19 (15–24)21 (17–27)0.092b
SGPT (U/L)15 (12–19)14 (12–18)0.514b
ACR ratio3.35 (2.47–5.97)
OPG (pg/ml)314 (171–504)392 (271–667)0.025*b
RANKL (pg/ml)545 (107–3377)234 (12–2046)0.037*b
RANK (pg/ml)43 (18–110)52 (18–91)0.946b
RANKL/OPG1.7 (0.41–7.22)0.64 (0.02–2.95)0.002*b
  1. Data are presented as mean ± standard deviation for normally distributed variables and median (interquartile range) for non normally distributed variables
  2. *: significance p < 0.05, **: significance p < 0.001
  3. a: Chi-square test for qualitative variables, b: Mann-Whitney U test for not normally distributed quantitative variables. c: t-test for normally distributed quantitative variables