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Table 1 Major findings

From: Does virtual reality reduce pain in pediatric patients? A systematic review

ID Title First author Publication year Country Sample size Age Study design Virtual reality pattern VR application
1 Virtual reality as complementary pain therapy in hospitalized patients with sickle cell disease Agrawal A.K. 2019 United States 31 13–20 Feasibility study Oculus Rift VR headset VR was used to manage pain of vaso-occlusive pain episodes (VOE) in patients with sickle cell disease (SCD).
2 Effectiveness of audio visual distraction using virtual reality eyeglasses versus tablet device in child behavioral management during inferior alveolar nerve block Al-Halabi M.N. 2018 Syria 102 6–10 Randomized Controlled Trial Virtual reality box (VR Box) VR was used to reduce pain in children behavioral management during inferior alveolar nerve block.
3 Effect of virtual reality headset for pediatric fear and pain distraction during immunization Chad R. 2018 United States 34 (17 children and 17 parents) Children: 6–17
Parents: 32–46
Pilot study VR Headset VR was used to reduce pain and fear during immunization.
4 Virtual Reality for Pediatric Needle Procedural Pain: Two Randomized Clinical Trials Chan E. 2019 Australia 252 4–11 Randomized Controlled Trial Google Pixel XL/Google Daydream VR was used to reduce the pain during needle-related procedures, in 2 environments: emergency department and outpatient pathology.
5 A Randomized Controlled Trial of the Use of Virtual Reality for Needle-Related Procedures in Children and Adolescents in the Emergency Department Dumoulin S. 2019 Canada 59 8–17 Randomized Controlled Trial eMagin z800 HMD VR was used to reduce the pain during needle-related procedures.
6 Effects of distraction using virtual reality technology on pain perception and anxiety levels in children during pulp therapy of primary molars Niharika P. 2018 India 40 4–8 Randomized Controlled Trial Google VR Box and Anti-Tank Virtual Reality 3D Glasses VR was used to reduce pain during pulp therapy in pediatric patients.
7 Effects of Virtual Reality and External Cold and Vibration on Pain in 7- to 12-Year-Old Children During Phlebotomy: A Randomized Controlled Trial Gerçeker G.Ö. 2018 United States 121 7–12 Randomized Controlled Trial Samsung Gear Oculus headset VR was used to reduce pain during phlebotomy.
8 The Effect of Virtual Reality Distraction on Pain Relief During Dressing Changes in Children with Chronic Wounds on Lower Limbs Hua Y. 2015 China 65 4–16 Prospective randomized study Head-mount display VR was used to reduce pain resulted from dressing changes in pediatric patients with Chronic Wounds on Lower Limbs.
9 Effect of virtual reality on adolescent pain during burn wound care Jeffs D. 2014 United States 30 10–17 Randomized Controlled Trial Tripod-arm device VR was used to reduce procedural pain during burn wound care.
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