Table 1 Characteristics of included studies
NO. | Author | Dopamine group | Epinephrine group | Jada scores | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Number | Age | Male (n) | Weight (g) | Mechanical ventilation requirement (n) | Methods | Number | Age | Male (n) | Weight (g) | Mechanical ventilation requirement (n) | Methods | |||
1 | Baske 2018 [15] | 20 | – | 13 | 1181 (892, 1540) g, median (interquartile range) | 20 | dopamine was initiated at 10 μg/kg/min, increased to 15μg/kg/min, thereafter to 20μg/kg/min (31–45 min) for neonatal septic shock | 20 | – | 14 | 1100 (926, 1400) g | 17 | epinephrine was initiated at 0.2μg/kg/min, increased to 0.3 μg/kg/min, thereafter to 0.4 μg/kg/min (31–45 min). | 4 |
2 | Ramaswamy 2016 [16] | 31 | 4 (0.8–8) years, median (interquartile range) | 15 | – | 17 | dopamine (in incremental doses, 10 to 15 to 20 μg/kg/min) till end points of resolution of shock for pediatric septic shock | 29 | 7 (1–11) years | 15 | – | 10 | epinephrine (0.1 to 0.2 to 0.3 μg/kg/min) till end points of resolution of shock | 4 |
3 | Ventura 2015 [17] | 63 | 39.6 ± 46.3 months | 35 | – | – | dopamine (5–10 μg/kg/min) through a peripheral or intraosseous line for pediatric septic shock | 57 | 56.9 ± 58.2, months | 35 | – | – | epinephrine (0.1–0.3 μg/kg/min through a peripheral or intraosseous line | 4 |