Fig. 5

Adherence (%) by reporting day and study center. It is possible to describe three phases (indicated by light background color): the 1st phase (a), lasting 6 days, during which adherence falls from 100 to 90%; the 2nd phase (b), lasting approximately 20 days, during which adherence fluctuates until reaching 88%; the 3rd phase (c) during which it declines to 80%. Reprinted with permission from [22]