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Table 5 The diagnostic efficacy indicators of each index for EBV-IM and EBV-HLH

From: Clinical warning of hemophagocytic syndrome caused by Epstein-Barr virus

 

AUC

95%CI

P value

Cut-off point

sensitivity

specificity

IgA(g/L)

0.884

0.811–0.957

< 0.001

0.965a

88.00%

73.20%

IgM(g/L)

0.889

0.793–0.984

< 0.001

1.145a

84.00%

87.50%

CD3 + (×109/L)

0.920

0.843–0.996

< 0.001

3.338a

82.80%

95.10%

CD4 + (×109/L)

0.877

0.797–0.957

< 0.001

0.787a

72.40%

96.70%

CD8 + (× 109/L)

0.912

0.830–0.944

< 0.001

1.526a

82.80%

95.10%

CD3-CD19 + (×109/L)

0.854

0.754–0.953

< 0.001

0.327a

72.40%

93.40%

NK(×109/L)

0.929

0.857–1.000

< 0.001

0.266a

82.10%

98.40%

Plasma EBV-DNA load (copies/mL)

0.838

0.686–0.989

< 0.001

47,250.000b

77.80%

94.70%

Total blood EBV-DNA load (copies/mL)

0.715

0.578–0.851

0.003

1,660,000.000b

64.00%

79.60%

D-Dimer (ug/L)

0.905

0.809–1.000

< 0.001

1721.500b

88.90%

90.20%

  1. athe data ≤ the value were considered positive, bthe data ≥ the value were considered positive