Fig. 2

a, b Subgroup analysis. a In accordance to positive familial history for atopy, a significant decrease in number of episodes of symptoms was described (*p < 0.05). b According to the age, children 1–3 years old showed an improvement in all symptoms, however, they become statistically significant only at the end of the 3 months of treatment (*p < 0.05). In children 3–6 years old and 6–12 years old, the therapeutic efficacy was assessed since the first month of treatment (*p < 0.05)