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Table 1 DIC diagnostic criteria of JSOGN

From: Risk factors and treatments for disseminated intravascular coagulation in neonates

BW

≥ 1,500g

< 1,500g

PLT

70×103/μL ≤ and 50% reduction within 24 hours

1 point

1 point

50×103/μL ≤ < 70×103/μL

1 point

1 point

< 50×103/μL

2 points

2 points

Fibrinogen

50mg/dL ≤ < 100mg/dL

1 point

-

< 50mg/dL

2 points

1 point

PT-INR

1.6 ≤ < 1.8

1 point

-

1.8 ≤

2 points

1 point

FDP or D-dimer

< 2.5 fold upper limit of normal range

-1 point

-1 point

2.5 fold upper limit of normal range ≤ < 10 fold upper limit of normal range

1 point

1 point

10 fold upper limit of normal range ≤

2 points

2 points

  1. JSOGNH Japan Society of Obstetrical, Gynecological & Neonatal Hematology, PLT platelet count, BW birth weight, PT-INR prothrombin time international ratio
  2. For a platelet count of ≥ 70×103 /μL, a point is added if the platelet count is reduced by 50% within 24 hours. A point is not added if the patients had thrombocytopenia due to myelosuppression disease
  3. For fibrinogen, a point is added if the underlying disease of the patient was an infection
  4. Since the upper limit of D-dimer is different among D-dimer kits, a point is added if FDP and D-dimer increased by 2.5 or 10 fold of the upper limit of normal