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Table 1 Clinical features of neonates born to mothers with perinatal confirmed SARS-CoV-2 infection

From: Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far

 AllDong et al. [30]Chen et al. [32]Li et al.
Wang et al. [34]Zhu et al.
Chen et al. [36]Liu et al. [37]Zeng et al.
Piersigilli et al. (unpublished)
Pregnant women6919119 (1 was a mother of twins)410331
Caesarean section53/69 (76.8%)19/9117/93/410/1026/331
Positive maternal test (SARS-CoV-2 quantitative RT-PCR on samples from the respiratory tract)68/69 (98.6%)19/9118/9 *4/410/1033/331
Median maternal age, years (range)30 (22–40)2928 (26–40)302830 (25–35)29.5 (23–34)30.5 (22–36)NA37
Median gestational age (GA) on admission, weeks (range)36 (26–39)3837 (36–39)353034 (31–39)37.5 (37–39)35.5 (32–38)NA26
Median onset of maternal symptoms to delivery, days (range)2.5 (0–26)263 (1–7)262.5 (0–6)NANANA2
Maternal fever on admission37/69 (53.6%)17/9118/103/48/108/330
Positive cord blood samples00 **0/600NANANANANA
Positive neonatal throat swab samples4/63 tested0 **0/6000/9;1 not tested0/3; 1 not tested0/103/331
Positive breastmilk samples000/6000/9; 1 not tested0/3; 1 not tested0/10NA0
Low birthweight (<  2500 g)14/70 (20%)02/9NA17/100NA3/331
Premature delivery24/70 (34.3%)04/9116/1016/104/331
Intrauterine foetal distress15/69 (22%) + 1 stillbirth0016/101/43/10 + 1 stillbirth02/332/9
Premature rupture of membranes6/70 (8.6%)02/9003/1001/103/330
  1. NA not available
  2. *The local CDC registered the mother of a couple of twins as a confirmed SARS-CoV-2 because of viral interstitial pneumonia at chest CT scan although RT-PCR returned negative
  3. **In the newborn reported by Dong et al.,they found virus-specific IgG and IgM, high levels of Interleukin 6 and 10, negative nasopharyngeal swab and no symptoms, since two hours from the delivery to the following three weeks