1st Author, Year (Ref) | Population; Country | Study Design | Outcome | Key results | Comments |
---|---|---|---|---|---|
Bernard, 1997 [45] | 455 children with sepsis, defined as fever, tachycardia, tachypnea, and acute failure of at least one organ system. | Randomized, double-blind, placebo-controlled trial | Mortality rate at 30 days from the sepsis | Mortality by day 30 did not differ significantly in the ibuprofen and placebo groups (37% vs 40%). In the ibuprofen group, there were significant declines in urinary levels of prostacyclin and thromboxane, temperature, heart rate, oxygen consumption, and lactic acidosis. | None |
Lamagni, 2008 [44] | 2607 adults and 318 children with severe Streptococcus pyogenes infection | Prospective, observational, study | STSS development | Patients who used NSAIDs had a 3-fold increased risk for STSS (OR 3.00, 95% CI 1.30–6.93, p = 0.01). | No data collected regarding time, dose, indications, and specific NSAIDs used. |
Demirel, 2012 [46] | 51 preterm infants with sepsis treated with Ibuprofen for PDA versus 38 preterm infants with sepsis without PDA not treated with Ibuprofen | Prospective, observational, study | Effects on the production of IL-6 and CRP | CRP and IL6 were significantly decreased at day 4th or 5th and 7th or 10th after sepsis diagnosis in the group of children treated with Ibuprofen for PDA (p = 0.02, p = 0.01, p = 0.03, p = 0.01, respectively) | Non-interventional study, with unclear exclusion criteria and relatively small sample size. |