Table 1 Allele and genotype frequencies of the selected SNPs in the study cohort
SNP (Gene) | Model | Genotype | Cases | Controls | OR (CI), p-value |
|---|---|---|---|---|---|
rs1532268 (c.524C > T) (MTRR) | Dominant | CT + TT CC | 86 35 | 75 46 | 0.25 (0.15–0.43), 2.4 × 10−7 |
Recessive | TT CT + CC | 14 107 | 3 118 | 5.15 (1.44–18.40), 0.005 | |
Alleles | T C | 0.41 0.59 | 0.2 0.8 | 5.73 (3.82–8.61), 5.11 × 10−7 | |
rs104894073 (c.886G > A) (GATA4) | Dominant | GA + AA GG | 84 37 | 85 36 | 0.19 (0.11–0.32), 6.7 × 10−10 |
Recessive | AA GA + GG | 6 115 | 2 119 | 3.0 (0.61–15.70), 0.15 | |
Alleles | A G | 0.37 0.63 | 0.16 0.84 | 3.08 (2.00–4.74), 8.36 × 10− 8 | |
rs699947 (c.-2578C > A) (VEGF) | Dominant | CA + AA CC | 103 18 | 71 50 | 0.25 (0.13–0.46), 4.7 × 10− 6 |
Recessive | CA + CC AA | 95 26 | 105 16 | 1.80 (0.90–3.55), 0.089 | |
Alleles | A C | 0.53 0.47 | 0.36 0.64 | 2.03 (1.41–2.92), 0.0001 | |
rs6867206 (g.51356860 T > C) (ISL1) | Dominant | TC + CC TT | 74 47 | 64 57 | 0.71 (0.43–1.19), 0.194 |
Recessive | TC + TT CC | 121 0 | 121 0 | – | |
Alleles | C T | 0.31 0.69 | 0.26 0.74 | 0.27 (0.85–1.89), 0.227 |