Table 1 Clinical characteristics of enrolled patients

Male

117 (39%)

Age at onset

6.7 ± 4.2

Family history

57 (19%)

Lack of symptoms

38 (12.7%)

Typical GI symptoms^a

242 (80.7%)

- Constipation

50 (16.7%)

- Diarrhea

111 (37%)

- Abdominal pain

71 (23.7%)

- Lack of appetite

72 (24%)

- Vomiting

44 (14.7%)

- Abdominal distension/meteorism

25 (8.3%)

- Weight loss

145 (48.3%)

- Short stature

62 (20.6%)

Non typical GI symptoms^a

58 (19.3%)

- Iron deficiency anemia

138 (46%)

- Headache

15 (5%)

- Asthenia/joint or muscular pain

56 (18.7%)

- oral trush

28 (9.3%)

Anti-tTG ≥ 100

194 (64.7%)

AI disorders^b

33 (11%)

Atopy

97 (32.3%)

Hypertransaminasemia

74 (24.7%)

Marsh 3b/3c^c

89 (61.8%)