Fig. 3

Bowel morphology after empagliflozin treatment. A MRI (day + 85): decreased wall thickness (max 6.5 mm), decreased diffusion restriction, decreased contrast enhancement in the distal ileum (total length: 5.5 cm) together with ileal stricture; stable mesenteric hypertrophy (creeping fat) and lymphadenopathy with no evidence of conglomerated bowel loops (right lower quadrant) are also shown. B-C. Ileocolonoscopy (day + 161): ileocecal valve ulcer and stricture with the impossibility to pass through with the scope (Paris classification A1b, L1, B2, G0; SES-CD: 3). D Histology (day + 161, colonic mucosa): minimal architectural distortion, increase of lamina propria, associated with muscularis mucosae hypertrophy (black arrow) and adequate gland representation indicating chronic mild colitis with histologic remission. SES-CD: simplified endoscopic score for Crohn’s disease