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Table 1 Classification of Infant’s Clinical Presentation according to NSC (available at https://neonatalsepsiscalculator.kaiserpermanente.org/) [7]

From: Brief comments on three existing approaches for managing neonates at risk of early-onset sepsis

Clinical Exam Description
Clinical Illness 1. Persistent need for NCPAP / HFNC / mechanical ventilation (outside of the delivery room)
2. Hemodynamic instability requiring vasoactive drugs
3. Neonatal encephalopathy /Perinatal depression
▪ Seizure
▪ Apgar Score at 5 min < 5
4. Need for supplemental O2 > 2 h to maintain oxygen saturations > 90% (outside of the delivery room)
Equivocal 1. Persistent physiologic abnormality > 4 h
▪ Tachycardia (HR > 160)
▪ Tachypnea (RR >  60)
▪ Temperature instability (> 100.4 °F or < 97.5 °F)
▪ Respiratory distress (grunting, flaring, or retracting) not requiring supplemental O2
2. Two or more physiologic abnormalities lasting for > 2 h
▪ Tachycardia (HR > 160)
▪ Tachypnea (RR >  60)
▪ Temperature instability (> 100.4 °F or < 97.5 °F)
▪ Respiratory distress (grunting, flaring, or retracting) not requiring supplemental O2
Note: abnormality can be intermittent
Well Appearing No persistent physiologic abnormalities