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Table 3 Percentage of bone penetration of the main antibiotics used in AHOM

From: Italian consensus on the therapeutic management of uncomplicated acute hematogenous osteomyelitis in children

Antibiotic Percentage of bone penetration
  Boselli 1999 [14] Landrsdorfer 2009 [15] Thabit 2019 [16]
BETA-LACTAMS
Amoxicillin 17–31% 18–20% 10% (amoxi-clavulanate)
Clavulanic 10–15%
Ampicillin 16% 11–71%
Sulbactam 17–71%
Piperacillin 18–23% 18–23% or 15% 15% (piperacillin-tazobactam)
Tazobactam 22–26% 22–26%
Flucloxacillin 8–15% 5–15% 65%
Oxacillin 11% 21%
CARBAPENEMS
Ertapenem 10–20% 35%
Meropenem 50%
CEPHALOSPORINS
Ceftriaxone 7–17%
Cefazolin 18% 18% 25%
Cefepime 46–76%
Cefuroxime 14–23%
Cefotaxime 8,8%
Ceftazidime 20–35% 54% 49%
MACROLIDES
Erythromycin 28.5–39% 18–28%
Azithromycin 250–630%
GLYCOPEPTIDES
Vancomycin 60.8% 5–67% 20–40%
Teicoplanin 14–290% 50–64%
AMINOGLYCOSIDES
Gentamicin 14–55% 16–33%
Amikacin 15–30%
OTHERS
Metronidazole 50%
Linezolida 23–51% 44%
Daptomycin 12–55% or 108% 20%
TMP-SMX 11–60% 15–50% 25%
Rifampicin 17–41% 20–25% 40%
Tigecyclinea 35–195% or 47%
Clindamycin 98.3% 21–45% 26%
  1. aNot registered for pediatric use