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Table 6 Suggested oral therapy in uncomplicated AHOM by age group

From: Italian consensus on the therapeutic management of uncomplicated acute hematogenous osteomyelitis in children

Age Oral therapy
Unknown aetiological agent (age < 5 years)a Cephalexin
OR
Amoxicillin-clavulanate +/− Rifampicin
Unknown aetiological agent (age > 5 years) Cephalexin
OR
Flucloxacillin
OR
Clindamycin
S. aureus Cephalexin
OR
Flucloxacillin
OR
Clindamycinb
OR
TMX-SMX + Rifampicinb
OR
Linezolidbc
K. kingae Amoxicillin-clavulanate
OR
Cefixime
OR
Cefpodoxime
OR
Cefazolin
OR
Trimethoprim/sulphamethoxazole
S. pyogenes Cephalexin
OR
Flucloxacillin
OR
Amoxicillin
  1. aOral antibiotic therapy is not indicated in infants < 3 months old
  2. bIf MRSA or PVL-SA is suspected or confirmed
  3. cNot registered for pediatric use