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Table 8 Proposed switch to oral therapy on the basis of intravenous therapy

From: Italian consensus on the therapeutic management of uncomplicated acute hematogenous osteomyelitis in children

Intravenous therapy Proposed oral therapy
Cefazolin Cephalexin
Amoxicillin-clavulanate Amoxicillin-clavulanate
Ampicillin Amoxicillin
Ampicillin-sulbactam Amoxicillin-clavulanate
Oxacillin Flucloxacillin
OR
Cephalexina
Clindamycin Clindamycin
OR
Trimethoprim/sulfamethoxazolea
Ceftriaxone Amoxicillin-clavulanate
Ceftriaxone
+
Clindamycin or glycopeptides
Trimethoprim/sulfamethoxazole + Rifampicin
Vancomycin Trimethoprim/sulfamethoxazole + Rifampicin
OR
Linezolidb
  1. aIf ingestion of tablets is difficult/compromised
  2. bNot registered for pediatric use