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Table 1 Demographic and laboratory data of patients and controls

From: IL-23/Th17 pathway and IL-17A gene polymorphism in Egyptian children with immune thrombocytopenic purpura

Parameter

ITP patients

(N = 60)

Control

(N = 50)

P-value

Age (year)

0.345

 Range

1–12

1–14

 Mean ± SD

5·5 ± 3·2

6·8 ± 3·9

Sex

0.254

 Male

38 (63.3%)

24 (48.0%)

 Female

22 (36.7%)

26 (52.0%)

Weight centile (th)

0.09

 Range

75–90

75–80

 Mean ± SD

49.8 ± 20.8

47.8 ± 18.5

Length/Heigh centile (th)

0.07

 Range

50–75

50–75

 Mean ± SD

64.8 ± 11.6

61.24 ± 12.4

Residence

0.234

 Rural

32 (53.0%)

28 (56.0%)

 Urban

28 (47.0%)

22 (44.0%)

Hb (gm/dL)

< 0.001*

 Range

7–11.5

11–12.4

 Mean ± SD

9.1 ± 1.2

11.6 ± 0.4

WBCs × 109/L

0.354

 Range

4–13

4.8–13.6

 Mean ± SD

6.8 ± 2

7.3 ± 2.7

Platelets ×  109/L

< 0.001*

 Range

9–67

218–461

 Mean ± SD

52.9 ± 25.6

280.3 ± 46.4

MPV, fl

0.006*

 Range

9.4–11.4

7.7–8.9

 Mean ± SD

11.2 ± 1.6

7.9 ± 5

Th17 (%)

< 0.001*

 Range

1–3.9

0.3–1.9

 Mean ± SD

2.1 ± 0.9

1.1 ± 0.4

IL-23 (pg/mL)

< 0.001*

 Range

109.6–378.6

34.9–140.7

 Mean ± SD

215.4 ± 79

86.4 ± 32.7

IL-17A (pg/mL)

< 0.001*

 Range

40.7–369

31–191.9

 Mean ± SD

92.4 ± 39

42.7 ± 19

  1. N number, SD standard deviation, Hb hemoglobin, WBCs white blood cells, MPV mean platelets volume
  2. *p-value < 0.05 = significant