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Table 1 Baseline characteristics of participants (n = 46)

From: High levels of unbound bilirubin are associated with acute bilirubin encephalopathy in post-exchange transfusion neonates

ABE No (n = 28) Yes (n = 18) P-value
Demographic data
 Age, mean (SD), hours 128.7 (94.2) 174.2 (67.6) 0.042
 Gestational age, mean (SD), weeks 38.8 (1.5) 38.3 (0.9) 0.205
 Birth weight, mean (SD), kilogram 3.28 (0.35) 3.25 (0.45) 0.825
 Weight, mean (SD), kilogram 3.14 (0.39) 3.13 (0.41) 0.923
 Male, No. (%) 13 (46.43%) 11 (61.11%) 0.331
Laboratory data
 TSB1, mean (SD), mg/dL 25.96 (5.53) 33.77 (5.94) < 0.001
 UB, mean (SD), mg/dL 23.74 (5.12) 30.35 (5.54) < 0.001
 TSB2, mean (SD), mg/dL 11.13 (3.32) 17.53 (6.27) < 0.001
 Blood glucose, mean (SD), mmol/L 5.3 (1.2) 6.9 (3.0) 0.017
 White blood cell, mean (SD), *109/L 13.2 (5.1) 14.2 (4.7) 0.508
 Blood platelet count, mean (SD), *109/L 289.7 (125.6) 264.0 (116.0) 0.493
 Red blood cell, mean (SD), *1012/L 4.07 (1.08) 3.29 (0.72) 0.010
 Hemoglobin, mean (SD), g/L 143.2 (35.5) 116.1 (29.6) 0.011
 Serum sodium, mean (SD), mmol/L 142.5 (3.0) 142.1 (2.6) 0.584
 Serum calcium, mean (SD), mmol/L 2.40 (0.25) 2.38 (0.17) 0.762
 Serum potassium, mean (SD), mmol/L 4.62 (0.52) 4.39 (0.38) 0.117
 Serum albumin, mean (SD), g/L 37.45 (2.80) 36.12 (4.16) 0.201
 Acidosis, No. (%) 5 (17.86%) 6 (33.33%) 0.230
 Hypoxia, No. (%) 1 (3.57%) 2 (11.11%) 0.552
Cause of severe hyperbilirubinemia
 Hemorrhage, No. (%) 6 (21.43%) 3 (16.67%) 0.691
 Hemolysis, No. (%) 16 (57.14%) 12 (66.67%) 0.518
 Infection, No. (%) 11 (39.29%) 8 (44.44%) 0.729
 Erythrocytosis, No. (%) 2 (7.14%) 0 (0.00%) 0.246
 Unknown reason, No. (%) 1 (3.57%) 3 (16.67%) 0.124
Treatment
 Iv immunoglobulins, No. (%) 6 (21.43%) 7 (38.89%) 0.199
 Receive phototherapy before ET, No. (%) 25 (89.29%) 11 (61.11%) 0.024
  1. TSB1:TSB at the start of ET
  2. TSB2:TSB at the end of the ET
  3. Hemorrhage: include scalp hematoma (n = 2), subarachnoid hemorrhage (n = 2), subdural hemorrhage(n = 1), and intracranial hemorrhage(n = 4) showed by MRI
  4. Hemolysis: include ABO haemolytic, RhD haemolytic, Autoimmune haemolytic and Glucose-6-phosphate Dehydrogenase defificiency
  5. Infection: include sepsis, pulmonary infection, intracranial infection and umbilical infection