Table 3 Unmet needs in the management of pediatric eosinophilic esophagitis (modified from reference [62])
From: Pediatric eosinophilic esophagitis: a review for the clinician
Diagnosis | Identify diagnostic and monitoring noninvasive biomarkers |
Increase the development of minimally invasive tools to acquire esophageal tissue | |
Validate score to predict disease activity | |
Diet therapy | Cross-reactivity between foods and airborne allergens |
The timeframe of reintroduction: 6 versus 8 versus 12 weeks | |
Predictive factors of food-elimination responsiveness | |
Long-term response in adherent patients | |
Drug maintenance therapy | Dose and persistence of maintenance treatment (PPI and steroids) |
Safety of long-term minimum effective dose | |
The predictive factor of steroid response and dependence | |
Other therapy | Validation of current available biologic agents |
Development of new agents targeting identified molecules | |
Identification of possible new targets for biologic therapy |