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Table 2 Course of clinical manifestations of Family 1 (Case 1 and Case 2), Family 2 (Case 3 and Case 4) and AHC phases reported by Mikati et al. (2000)

From: Alternating Hemiplegia of Childhood: neurological comorbidities and intrafamilial variability

  Family 1 Family 2 Mikati et al. (2000)
Case 1 Case 2 Case 3 Case 4 AHC phases
Age 0–24 mo 24–28 mo 3–7 y 7–11 y 11–19 y 0–24 mo 24–28 mo 3–7 y 7–11 y 11–19 y 0–1 y 1–5 y 6–7 y 0–1 y 1–5 y 6–11 y Phase 1 Phase 2 Phase 3
Features (0–1 y) (2–5 y) (+5y)
Dystonic induced events +++ + ++ +
Abnormal ocular movements +++ + ++ + + +++
DD/ID +/− +/− +/− +/− +/− +/− +/− +/− +/− +/− +/− +/− +/− +/− +/− + +++ +++
Autonomic phenomena ++ ++ + + ++ + + + + ++
Hemiplegic attacks + ++ +++ ++ + + + ++ + ++ + +++ +/− + +++ ++
Tonic/dystonic attacks + ++ +++ ++ + + + ++ + +/− ++ + +++ + + +++ ++
Acute encephalopathy ++ ++
Epileptic seizures ++ + +++ + + +
Headache with aura + +++ + ++
Walking problems + + + + + + + + + + + +
  1. Abbreviations: Level of severity are indicated from +/− to +++, DD/ID Developmental Delay/Intellectual Disability