Altered microstructure of the splenium of corpus callosum is associated with neurodevelopmental impairment in preterm infants with necrotizing enterocolitis

Table 2 Regional and total brain volume of preterm infants with and without NEC

Region of interest	Without NEC (n = 66)	With NEC (n = 20)	p value	Adjusted p value^*
Cortical gray matter, cm³	147.61 ± 41.97	140.80 ± 34.83	0.545	0.116
Cerebral white matter, cm³	124.58 ± 67.00	102.72 ± 11.62	0.022	0.512
Deep gray matter, cm³	23.59 ± 5.21	21.30 ± 3.25	0.034	0.078
Hippocampus, cm³	2.65 ± 1.22	2.23 ± 0.72	0.180	0.146
Amygdala, cm³	1.34 ± 0.69	1.07 ± 1.03	0.214	0.533
Cerebellum, cm³	20.77 ± 9.80	18.84 ± 5.19	0.439	0.448
Brain stem, cm³	5.76 ± 1.63	5.05 ± 1.22	0.104	0.182
Cerebrospinal fluid, cm³	78.53 ± 32.50	61.99 ± 15.68	0.047	0.144
Total intracranial volume, cm³	404.83 ± 109.82	354.00 ± 40.54	0.027	0.102^‡

Data are expressed as mean ± standard deviation
^*General linear model with the group as a fixed factor, sex, PMA at MRI, and total intracranial volume as covariates
^‡Adjusted by Gestational age, head circumference, and PMA at MRI
The significance level was corrected from 0.05 to 0.005 (0.05/9) by the Bonferroni correction method
Abbreviations: NEC necrotizing enterocolitis, PMA postmenstrual age, MRI magnetic resonance imaging

ISSN: 1824-7288