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Table 2 Regional and total brain volume of preterm infants with and without NEC

From: Altered microstructure of the splenium of corpus callosum is associated with neurodevelopmental impairment in preterm infants with necrotizing enterocolitis

Region of interest Without NEC
(n = 66)
With NEC
(n = 20)
p value Adjusted p value*
Cortical gray matter, cm3 147.61 ± 41.97 140.80 ± 34.83 0.545 0.116
Cerebral white matter, cm3 124.58 ± 67.00 102.72 ± 11.62 0.022 0.512
Deep gray matter, cm3 23.59 ± 5.21 21.30 ± 3.25 0.034 0.078
Hippocampus, cm3 2.65 ± 1.22 2.23 ± 0.72 0.180 0.146
Amygdala, cm3 1.34 ± 0.69 1.07 ± 1.03 0.214 0.533
Cerebellum, cm3 20.77 ± 9.80 18.84 ± 5.19 0.439 0.448
Brain stem, cm3 5.76 ± 1.63 5.05 ± 1.22 0.104 0.182
Cerebrospinal fluid, cm3 78.53 ± 32.50 61.99 ± 15.68 0.047 0.144
Total intracranial volume, cm3 404.83 ± 109.82 354.00 ± 40.54 0.027 0.102
  1. Data are expressed as mean ± standard deviation
  2. *General linear model with the group as a fixed factor, sex, PMA at MRI, and total intracranial volume as covariates
  3. Adjusted by Gestational age, head circumference, and PMA at MRI
  4. The significance level was corrected from 0.05 to 0.005 (0.05/9) by the Bonferroni correction method
  5. Abbreviations: NEC necrotizing enterocolitis, PMA postmenstrual age, MRI magnetic resonance imaging