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Table 3 Network parameters of diffusion tensor analysis in preterm infants with and without NEC

From: Altered microstructure of the splenium of corpus callosum is associated with neurodevelopmental impairment in preterm infants with necrotizing enterocolitis

Region of interest Without NEC
(n = 66)
With NEC
(n = 20)
Unadjusted p value* Adjusted p value** Adjusted p value
+ TPN days
gCC
 FA 0.181 ± 0.027 0.175 ± 0.012 0.841 0.509 0.386
 MD 1.434 ± 0.129 1.445 ± 0.107 0.883 0.399 0.280
sCC
 FA 0.185 ± 0.032 0.173 ± 0.013 0.109 0.098 0.129
 MD 1.446 ± 0.151 1.543 ± 0.108 0.002 0.001 0.001
ltCST
 FA 0.261 ± 0.041 0.257 ± 0.032 0.891 0.207 0.221
 MD 1.230 ± 0.110 1.297 ± 0.082 0.003 0.001 0.001
rtCST
 FA 0.267 ± 0.038 0.261 ± 0.031 0.473 0.070 0.068
 MD 1.296 ± 0.107 1.303 ± 0.122 0.720 0.129 0.160
ltILF
 FA 0.181 ± 0.028 0.170 ± 0.015 0.109 0.047 0.038
 MD 1.484 ± 0.139 1.487 ± 0.101 0.620 0.029 0.743
rtILF
 FA 0.182 ± 0.027 0.174 ± 0.014 0.306 0.107 0.122
 MD 1.406 ± 0.132 1.407 ± 0.117 0.736 0.586 0.515
  1. Data are expressed as mean ± standard deviation
  2. *For non-normal distribution, Mann-Whitney U Test was used to compare the groups
  3. **Adjusted for gestational age and PMA at MRI; Quade’s nonparametric rank analysis of covariance was used to compare the groups
  4. Adjusted by gestational age, PMA at MRI, and TPN days; Quade’s nonparametric rank analysis of covariance was used to compare the groups
  5. The significance level was corrected from 0.05 to 0.008 (0.05/6) by the Bonferroni correction method
  6. Abbreviations: NEC necrotizing enterocolitis, FA fractional anisotropy, MD mean diffusivity, gCC corpus callosum genu, sCC corpus callosum splenium, ltCST left corticospinal tract, rtCST right corticospinal tract, ltILF left inferior longitudinal fiber, rtILF right inferior longitudinal fiber, PMA postmenstrual age, MRI magnetic resonance imaging, TPN total parenteral nutrition