Altered microstructure of the splenium of corpus callosum is associated with neurodevelopmental impairment in preterm infants with necrotizing enterocolitis

Table 5 Multiple regression analysis for the BSID-III composite scores in preterm infants*

BSID-III composite scores	MD, sCC (10⁻³ mm²/s)		GA		PMA at MRI
BSID-III composite scores	Coefficient (SE)	p value	Coefficient (SE)	p value	Coefficient (SE)	p value
Cognitive score	−18.414 (10.791)	0.092	1.209 (0.580)	0.041	0.665 (0.842)	0.432
Language score	−28.336 (12.402)	0.025	0.405 (0.667)	0.546	−0.131 (0.967)	0.892
Motor score	−41.913 (13.254)	0.002	1.080 (0.713)	0.134	−0.425 (1.034)	0.682
	MD, ltCST (10⁻³ mm²/s)		GA		PMA at MRI
	Coefficient (SE)	p value	Coefficient (SE)	p value	Coefficient (SE)	p value
Cognitive score	−7.840 (15.431)	0.613	1.276 (0.591)	0.034	0.696 (0.870)	0.426
Language score	−22.770 (17.840)	0.206	0.469 (0.683)	0.495	−0.198 (1.006)	0.845
Motor score	−37.421 (19.380)	0.058	1.161 (0.742)	0.122	−0.564 (1.093)	0.608

All regression analyses for each Bayley composite score included MD (sCC or ltCST), GA, and PMA at MRI scan
Abbreviations: BSID-III Bayley Scales of Infant and Toddler Development-III, MD mean diffusivity, sCC corpus callosum splenium, GA gestational age, PMA postmenstrual age, SE standard error, ltCST left corticospinal tract, MRI magnetic resonance imaging
^*Includes 75 preterm infants (19 with NEC, 56 without NEC) out of 86 preterm infants

ISSN: 1824-7288