From: Peculiar characteristics of new-onset Type 1 Diabetes during COVID-19 pandemic
Group I | Group II | P | ||
---|---|---|---|---|
Clinical presentation | ||||
Severe DKA (pH < 7.1, yes%) | 11/132 (8.4%) | 9/40 (22.5%) | 0.01 | 0.04* |
Moderate DKA (pH < 7.2, yes%) | 18/132 (13.6%) | 6/40 (15%) | ||
Mild DKA (pH < 7.3, yes%) | 19/132 (14.4%) | 7/40 (17.5%) | ||
No DKA (pH > 7.3, yes%) | 84/132 (63.6%) | 18/40 (45%) | 0.03 | |
Blood Gas Analysis | ||||
pH | 7.28 ± 0.12 | 7.23 ± 0.14 | 0.01 | |
HCO3− (mmol/L) | 16.8 ± 6.3 | 14.8 ± 7.8 | 0.15 | |
B.E | -10.8 ± 10.4 | -13.8 ± 9.7 | 0.13 | |
Glycemic Metabolism | ||||
Glycemia (mg/dL) | 395 ± 143 | 399 ± 130 | 0.81 | |
HbA1c (mmol/mol) | 103.7 ± 26 | 107.0 ± 27.6 | 0.46 | |
C-peptide (ng/mL) | 0.59 ± 0.56 | 0.50 ± 0.51 | 0.12 | |
T1D Autoimmunity | ||||
GAD Ab (U/ml) | 279 ± 515 | 464 ± 1105 | 0.27 | |
IA2 Ab (UI/mL) | 341 ± 867 | 111 ± 145 | 0.11 | |
Insula Ab (positive/negative) | 29/103 | 14/26 | 0.09 | |
Celiac Screening | ||||
Anti-TG IgA (positive/negative) | 5/127 | 6/34 | 0.02 | |
Anti-TG IgG (positive/negative) | 2/130 | 4/36 | 0.02 | |
EMA (positive/negative) | 7/125 | 2/38 | 0.94 | |
Thyroid Function | ||||
TSH (µIU/mL) | 2.47 ± 1.24 | 2.34 ± 2.02 | 0.07 | |
fT4 (ng/dL) | 1.24 ± 0.24 | 1.04 ± 0.13 | 0.001 | |
TPO Ab (IU/mL) | 0/132 | 1/39 | 0.07 | |
Tg Ab (IU/mL) | 0/132 | 1/39 | 0.07 | |
Lipid profile | ||||
Total cholesterol (mg/dL) | 153 ± 33 | 158 ± 27 | 0.47 | |
HDL Cholesterol (mg/dL) | 45 ± 13 | 40 ± 7 | 0.14 | |
LDL Cholesterol (mg/dL) | 92 ± 31 | 100 ± 24 | 0.30 | |
Tryglicerides (mg/dL) | 94 ± 54 | 116 ± 61 | 0.01 | |
Tg/HDL ratio | 2.04 ± 1.18 | 3.17 ± 2.24 | 0.004 |