Skip to main content

Table 2 Baseline clinical and laboratory characteristics of newly diagnosed children with type 1 diabetes before (Group I) and during (Group II) COVID-19 pandemic

From: Peculiar characteristics of new-onset Type 1 Diabetes during COVID-19 pandemic

 

Group I

Group II

P

Clinical presentation

 Severe DKA (pH < 7.1, yes%)

11/132 (8.4%)

9/40 (22.5%)

0.01

0.04*

 Moderate DKA (pH < 7.2, yes%)

18/132 (13.6%)

6/40 (15%)

 

 Mild DKA (pH < 7.3, yes%)

19/132 (14.4%)

7/40 (17.5%)

 

 No DKA (pH > 7.3, yes%)

84/132 (63.6%)

18/40 (45%)

0.03

Blood Gas Analysis

 pH

7.28 ± 0.12

7.23 ± 0.14

0.01

 HCO3 (mmol/L)

16.8 ± 6.3

14.8 ± 7.8

0.15

 B.E

-10.8 ± 10.4

-13.8 ± 9.7

0.13

Glycemic Metabolism

 Glycemia (mg/dL)

395 ± 143

399 ± 130

0.81

 HbA1c (mmol/mol)

103.7 ± 26

107.0 ± 27.6

0.46

 C-peptide (ng/mL)

0.59 ± 0.56

0.50 ± 0.51

0.12

T1D Autoimmunity

   

 GAD Ab (U/ml)

279 ± 515

464 ± 1105

0.27

 IA2 Ab (UI/mL)

341 ± 867

111 ± 145

0.11

 Insula Ab (positive/negative)

29/103

14/26

0.09

Celiac Screening

 Anti-TG IgA (positive/negative)

5/127

6/34

0.02

 Anti-TG IgG (positive/negative)

2/130

4/36

0.02

 EMA (positive/negative)

7/125

2/38

0.94

Thyroid Function

 TSH (µIU/mL)

2.47 ± 1.24

2.34 ± 2.02

0.07

 fT4 (ng/dL)

1.24 ± 0.24

1.04 ± 0.13

0.001

 TPO Ab (IU/mL)

0/132

1/39

0.07

 Tg Ab (IU/mL)

0/132

1/39

0.07

Lipid profile

 Total cholesterol (mg/dL)

153 ± 33

158 ± 27

0.47

 HDL Cholesterol (mg/dL)

45 ± 13

40 ± 7

0.14

 LDL Cholesterol (mg/dL)

92 ± 31

100 ± 24

0.30

 Tryglicerides (mg/dL)

94 ± 54

116 ± 61

0.01

 Tg/HDL ratio

2.04 ± 1.18

3.17 ± 2.24

0.004

  1. *Severe/moderate vs mild/no-DKA