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Table 1 Distribution of endocrine stimulation test according to suspected diagnosis and pathological tests in 2019 and 2020 (a ITT were performed to detect both GHD and CAI simultaneously)

From: Reduction in pediatric growth hormone deficiency and increase in central precocious puberty diagnoses during COVID 19 pandemics

  

2019

2020

Suspected diagnosis

Stimulation test

N of performed tests

N of pathological tests

% of pathological tests

N of performed tests

N of pathological tests

% of pathological tests

GHD

ATT

95

39

41%

60

25

42%

ATT + GHRHT

1

1

100%

   

CTT

   

1

1

100%

ITTa

31

25

81%

19

16

84%

NC-CAH

SDST

52

0

0%

56

1

2%

CPP

LHRHT

48

24

50%

54

28

52%

CAI

ITTa

31

5

16%

19

4

21%

LDST

16

1

6%

13

1

8%

CRHT

   

1

0

0%

HH

LHRHT

18

5

28%

27

1

4%

AGHD

ATT + GHRHT

17

0

0%

15

1

7%

CH

TRHT

   

1

1

100%

OG

OGTT

   

4

2

50%

  1. AGHD Adult Growth Hormone Deficiency, ATT Arginine Tolerance Test, ATT + GHRHT Arginine Tolerance Test + Growth Hormone Releasing Hormone Test, CAI Central Adrenal Insufficiency, CH Central Hypothyroidism, CPP Central Precocious Puberty, CRHT Corticotropin-Releasing Hormone Test, CTT Clonidine Tolerance Test, GHD Growth Hormone Deficiency, HH Hypogonadotropic Hypogonadism, ITT Insulin Tolerance Test, LDST Low-Dose Synacthen Test, LHRHT Luteinizing Hormone-Releasing Hormone Test, NC-CAH Non-Classical Congenital Adrenal Hyperplasia, OG OverGrowth, OGTT Oral Glucose Tolerance Test, SDST Standard-Dose Synacthen Test, TRHT Thyrotropin Releasing Hormone