Table 3 Main effects of topical calcineurin inhibitors compared to topical corticosteroids
Parameter | Topical Pimecrolimus (810 Da) | Topical Tacrolimus (822 Da) | Topical Corticosteroids (<500 Da) |
|---|---|---|---|
Activity on cells | T Lymphocytes, Mast cells, | T Lymphocytes, Mast cells, Eosinophils, Basophils, Langherans cells, | T Lymphocytes, Mast cells, Eosinophils, Basophils, Langherans cells, Keratinocytes, Endothelial cells, Fibroblasts |
Cytokines | IL-2, IL-3, IL-4, IL-5,IL-13,IL-33, TNF-α, INF-γ, GM-CSF | IL-2, IL-3, IL-4, IL-5,IL-13,IL-31,IL-33, TNF-α, INF-γ, GM-CSF | IL-1,IL-2, IL-3, IL-4, IL-5,IL-6, IL-13,IL-31,TNF-α, INF-γ, GM-CSF,TSLP |
Inhibition function and Apoptosis of Langherans cells | - | + | ++ |
Absorption through the skin | + | ++ | +++ |
Atrophogenic activity | - | - | +++ |