Table 2 The area under the curve (AUC), cut-off values, sensitivity, and specificity for biomarkers invasive aspergillosis cases
sTREM-1 | Procalcitonin | Lactate dehydrogenase | C-reactive protein | White blood cells | Erythrocyte sedimentation rate | |
|---|---|---|---|---|---|---|
AUC | 0.7 | 0.8 | 0.9 | 0.9 | 0.5 | 0.8 |
95% CIa | 0.6% to 0.8% | 0.75% to 0.84% | 0.85% to 97% | 0.85% to 0.94% | 0.45% to 0.58% | 0.73% to 0.85% |
P-value | 0.003 | < 0.0001 | < 0.0001 | < 0.0001 | 0.29 | < 0.0001 |
Cut- off Value | > 190 | > 260 | > 252 | > 7 | ≤ 4930 | > 23 |
Sensitivity | 71.2% | 80.8% | 91.8% | 90.4% | 49.3% | 83.6% |
95% CI | 59% to 81% | 70% to 88.2% | 83.2% to 96.2% | 81% to 96% | 37% to 61% | 73% to 91% |
Specificity | 100% | 100% | 100% | 100% | 100% | 94.4% |
95% CI | 81.5% to100% | 81.5% to100% | 81.5% to100% | 81.5% to100% | 81.5% to100% | 72.7% to 99.9% |
PPVa | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 98.4 |
NPVa | 46.2 | 56.2 | 75 | 72 | 32.7 | 58.6 |