Skip to main content

Table 4 Associations between the SCN1A-A3184G genotypes and characteristics of the patients

From: Polymorphisms of the sodium voltage-gated channel, alpha subunit 1 (SCN1A -A3184G) gene among children with non-lesional epilepsy: a case-control study

Characteristics

Epilepsy Cases

AEDs resistant group

AEDs responders

p value

Genotypes

AG(n = 244)

AA(n = 82)

AG(n = 120)

AA(n = 43)

AG(n = 124)

AA (n = 39)

Family historya

      

p1 = 0.268

 Negative

150(61.5)

56(68.3)

60(50)

32(74.4)

90(72.6)

24(61.5)

p2 = 0.006*

 Positive

94(38.5)

26(31.7)

60(50)

11(25.6)

34(27.4)

15(38.5)

p3 = 0.19

Types of seizuresa

 Tonic-clonic

176(72.1)

52(63.4)

97(80.8)

27(62.8)

79(63.7)

25(64.1)

p1 = 0.002*

 Tonic

25(10.2)

19(23.2)

0

10(23.3)

25(20.2)

9(23.1)

p2 < 0.001*

 Myoclonic

6(2.5)

6(7.3)

6(5)

6(14)

0

0

p3 = 0.262

 Clonic

10(4.1)

0

0

0

10(8.1)

0

 Absence

27(11.1)

5(6.1)

17(14.2)

0

10(8.1)

5(12.8)

EEGa

 Normal

60(24.6)

46(56.1)

11(9.1)

22(51.2)

49(39.5)

24(61.5)

p1 < 0.001*

 Generalized epileptiform activity

184(75.4)

36(43.9)

109(90.9)

21(48.8)

75(60.5)

15(38.5)

p2 < 0.001*

p3 = 0.016*

AEDs a

 Topiramate

12(4.9)

0

12(10)

0

0

0

p1 = 0.04*

p2 = 0.03*

 Carbamazepine /Oxcarbazepine

50(20.5)

22(26.8)

11(9.2)

17(39.5)

39(31.5)

5(12.8)

p1 = 0.231

p2 = 0.03*

p3 = 0.02*

 Levetiracetam

86(35.2)

25(30.5)

48(40)

20(46.5)

38(30.6)

5(12.8)

p1 = 0.432

p2 = 0.457

p3 = 0.028*

 Valproic acid

215(88.1)

66(80.5)

115(95.8)

32(74.4)

100(80.6)

34(87.2)

p1 = 0.083

p2 < 0.001*

p3 = 0.352

Duration since the last seizure (months)b

3(0.75–5)

3(0.94–9)

2(1–6)

3(0.75–3)

18(12–24)

13(12–24)

p1 = 0.088

p2 = 0.029*

p3 = 0.139

Age of the first seizure attack (years)b

2(1–5)

1(0.33–3)

3(0.75–6)

3(1–9)

3(1–5)

2.5(0.67–8)

p1 = 0.015*

p2 = 0.03*

p3 = 0.229

Frequency of seizures (per month)b

13(12–24)

12(6–24)

2(1–5)

1(0.33–4)

0

0.17(0.17–0.17)

p1 = 0.004*

p2 = 0.05*

  1. Data were expressed as numbers a (percent) and median b (interquartile range), and compared using the chi-square a and Monto Carlo tests a, and Mann-Whitney test b
  2. AEDs Antiepileptic Drugs, Epilepsy cases AEDs responders plus resistant cases, EEG Electroencephalogram, N Number, P Probability, P1 for the AG versus AA genotypes in epilepsy cases, P2 for the AG versus AA genotypes in the AEDs-resistant group, P3 for the AG versus AA genotypes in AEDs-responders
  3. *P ≤ 0.05 is significant