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Table 2 Comparison of the concentration of selected cytokines and chemokines in subgroups

From: Assessment of selected interleukins (IL-6, IL-17A, IL-18, IL-23) and chemokines (RANTES, IP-10) in children with acute and chronic urticaria

Group/Parameter

 

Urticaria (n = 64)

Control group (n = 40)

IL-6

(pg/ml)

AU (n = 32)

13.27 (10.25–15.5)*

7.42

(6.21–8.45)

CU (n = 32)

13.91 (11.32–15.71)*

Mild CU (n = 14)

13.82 (11.4–14.53) *

Moderate CU (n = 8)

12.72 (11.09–14.43) *

Severe CU (n = 10)

15.71 (11.35–17.82) *

IL-17A (pg/ml)

AU (n = 32)

41.5 (38.35–44.15) *

27.13

(20.37–36.45)

CU (n = 32)

41.4 (38.55–48.25) *

Mild CU (n = 14)

42.95 (39.6–47.6) *

Moderate CU (n = 8)

40.5 (34.3–45.55) *

Severe CU (n = 10)

41.45 (38.4–50.2) *

IL-18

(pg/ml)

AU (n = 32)

114.2 (100.45–125.5) *

133.25

(122.95–142.15)

CU (n = 32)

115.8 (102.5–129.5) *

Mild CU (n = 14)

115.05 (101.5–130.1) *

Moderate CU (n = 8)

111.9 (101.9–123.35)*

Severe CU (n = 10)

123.2 (104.7–132.1)*

IL-23

(pg/ml)

AU (n = 32)

376.5 (308–434.5) *

603.0

(527.5–674.0)

CU (n = 32)

361.5 (289.0–462.0) *

Mild CU (n = 14)

307.0 (289.0–364.0) *

Moderate CU (n = 8)

459.0 (411.0–506.5) *

Severe CU (n = 10)

365.0 (275.0–463.0) *

RANTES

(pg/ml)

AU (n = 32)

3791.0 (2896.5–4516.5) *

5822.0

(5337.5–6261)

CU (n = 32)

3735.5 (3372.5–4676.5) *

Mild CU (n = 14)

4190.0 (3381.0–5127.0) */ **

Moderate CU (n = 8)

3140.0 (2806.5–3596.0) */***

Severe CU (n = 10)

3871.5 (3725.0–4271.0) *

IP-10

(pg/ml)

AU (n = 32)

48.25 (41.95–51.2) *

73.25

(65.85–85.6)

CU (n = 32)

48.0 (39.95–50.35) *

Mild CU (n = 14)

49.3 (43.2–50.6) *

Moderate CU (n = 8)

45.3 (38.1–49.15) *

Severe CU (n = 10)

47.45 (39.7–50.2) *

  1. Data presented as median (Q25 - Q75)
  2. AU acute urticaria, CU chronic urticaria, RANTES Regulated upon Activation Normal T-cell Expressed and Secreted, IP-10 - IFN-γ-inducible protein-10
  3. *p < 0.05 in comparison to the control group
  4. **p < 0.05 children with mild CU vs moderate CU
  5. ***p < 0.05 children with moderate CU vs severe CU