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Fig. 5 | Italian Journal of Pediatrics

Fig. 5

From: SIGIRR-caspase-8 signaling mediates endothelial apoptosis in Kawasaki disease

Fig. 5

SIGIRR overexpression alleviated coronary artery injury in a murine model of KD. A Heart tissues were harvested on 28 day after CAWS injection, and the representative images from H&E staining were shown. Magnification: × 200. Scale bar = 100 μm. B-G The protein expression of SIGIRR, TLR4, cleaved caspase-8 and cleaved caspase-3, and BAX/Bcl-2 ratio in the heart tissues were determined by Western blotting. H DNA fragmentation in the endothelial cells was assessed by co-localized staining of TUNEL (green) and CD31 (an endothelial marker, red) (n = 5). Magnification: × 200. Scale bar = 50 μm. * P < 0.05 versus PBS group, and # P < 0.05 versus CAWS group

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