Table 5 Associations between empirical antibiotics treatment and clinical outcome in VPIs
Outcomes | Antibiotic exposure | aORa(95% CI) ≤4d vs 0db | aORa(95% CI) > 4d vs 0db | aORa(95% CI) > 4d vs ≤4dc | ||
|---|---|---|---|---|---|---|
non-antibiotic(n = 152) | EAT ≤4 days (n = 374) | EAT > 4 days (n = 1308) | ||||
NEC ≥ stage2 | 1 (0.7) | 6 (1.6) | 85 (6.5) | 1.45 (0.17 ~ 12.82) | 7.68 (1.14 ~ 54.75) | 5.42 (1.94 ~ 14.80) |
HAI | 11 (7.2) | 42 (11.2) | 180 (13.8) | 0.96 (0.71 ~ 1.28) | 1.32 (0.85 ~ 1.47) | 1.28 (0.78 ~ 1.43) |
hsPDA | 6 (3.9) | 24 (6.4) | 219 (16.7) | 1.25 (0.42 ~ 3.56) | 3.28 (1.48 ~ 9.03) | 2.75 (1.54 ~ 4.88) |
IVH (grade 3 or 4) | 1 (0.7) | 3 (0.8) | 22 (1.7) | 0.70 (0.06 ~ 7.15) | 0.85 (0.14 ~ 6.44) | 1.35 (0.46 ~ 4.25) |
PVL | 2 (1.3) | 13 (3.5) | 38 (2.9) | 2.65 (0.59 ~ 12.05) | 1.48 (0.33 ~ 6.50) | 0.62 (0.42 ~ 1.26) |
Moderate and severe BPD | 3 (2.0) | 30 (8.0) | 147 (11.2) | 3.75 (0.74 ~ 19.05) | 3.24 (0.77 ~ 13.28) | 0.85 (0.48 ~ 2.08) |
PNAC | 4 (2.6) | 15 (4.0) | 112 (8.6) | 1.23 (0.65 ~ 3.44) | 2.25 (0.78 ~ 8.34) | 1.45 (0.93 ~ 1.77) |
ROP requiring intervention | 2 (1.3) | 3 (0.8) | 34 (2.6) | 0.24 (0.02 ~ 3.61) | 0.62 (0.06 ~ 5.85) | 2.43 (0.47 ~ 10.34) |