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Table 2 Recommendations for the pharmacological management of IBD after the peak of the COVID-19 pandemic (adapted from the SIGENP position paper) [16]

From: Pediatric Gastroenterology and Hepatology in Italy before and after the COVID-19: Lessons learned and management changes by SIGENP

Topic

Recommended

Steroids for induction

Yes (accelerated steroid weaning if clinically indicated)

Suspension of immunomodulators

 ▪As monotherapy

No

 ▪As combination therapy

No

Suspension of biologics

 ▪As monotherapy

No

 ▪As combination therapy

No

 Start of immunosuppressants or anti-TNF-α

Yes

 Intervals and doses of anti-TNF-α

Regular

 RT-PCR/serological screening for SARS-CoV-2 before starting anti-TNF-α therapy

No

 Vedolizumab and ustekinumab use

Yes (not contraindicated)

  1. TNF-α, tumor necrosis factor-α; RT-PCR, real time-polymerase chain reaction; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2