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Table 2 Variance analysis in the complete group of children with obesity (n = 63)

From: Changes in liver enzymes are associated with changes in insulin resistance, inflammatory biomarkers and leptin in prepubertal children with obesity

 

1er Tercile ALT

2º Tercile ALT

3er Tercile ALT

F

p

ALT (U/L)

15.48 ± 0.36

19.26 ± 0.18

24.18 ± 0.72

209.83

 < 0.001

Age (years)

8.69 ± 0.24

9.10 ± 0.19

8.97 ± 0.19

1.18

0.318

BMI (Kg/m2)

21.17 ± 1.19

22.88 ± 0.39

24,68 ± 0.47

4.91

0.025

SDS-BMI

2.46 ± 0.31

2.71 ± 0.17

3.50 ± 0.202

4.90

0.017

WC

71.95 ± 1.48

74.51 ± 1.37

78.40 ± 1.94

3.91

0.028

Glucose (mmol/L)

5.05 ± 0.08

4.98 ± 0.09

5.11 ± 0.06

0.72

0.495

Insulin (pmol/L)

43.06 ± 3.43

47.41 ± 3.65

59.44 ± 3.72

4.17

0.023

HOMA-IR

1.275 ± 0.11

1.491 ± 0.11

1.791 ± 0.12

5.07

0.011

Leptin (ng/mL)

16.61 ± 1.74

21.37 ± 2.17

26.35 ± 2.27

5.29

0.009

AST (U/L)

23.10 ± 0.90

23.82 ± 0.48

25.26 ± 0.96

1.99

0.150

BChE (U/L)

9514.8 ± 314.4

10,026.6 ± 145.8

10,294.2 ± 299.4

2.47

0.098

SBP (mm Hg)

98.71 ± 1.59

100.86 ± 1.12

100.38 ± 1.67

0.50

0.605

DBP (mm Hg)

60.43 ± 1.46

58.67 ± 0.90

59.81 ± 1.26

0.55

0.581

TC (mmol/L)

4.46 ± 0.12

4.44 ± 0.11

4.50 ± 0.17

0.06

0.943

TG (mmol/L)

0.78 ± 0.04

0.81 ± 0.04

0.92 ± 0.06

2.01

0.147

HDL-c (mmol/L)

1.37 ± 0.05

1.35 ± 0.03

1.36 ± 0.05

0.047

0.934

CRP (nmol/L)

18.96 ± 4.48

16.48 ± 2.47

25.10 ± 3.31

1.58

0.219

IL-6 (pg/mL)

1.36 ± 0.18

1.47 ± 0.08

1.52 ± 0.21

0.21

0.784

NLR

1.26 ± 0.14

1.05 ± 0.05

1.19 ± 0.07

1.37

0.266

PLR

97.27 ± 5.97

109.59 ± 6.39

103.27 ± 5.69

1.10

0.338

sICAM-1 (ng/mL)

278.51 ± 11.61

266.64 ± 8.33

267.40 ± 7.81

0.53

0.594

  1. Results after treatment for nine months, stratified by ALT divided into terciles
  2. ALT Alanine aminotransferase, BMI Body mass index, WC Waist circumference, HOMA-IR homeostasis model assessment for insulin resistance, AST Aspartate aminotransferase, BChE Butyryl cholinesterase, SBP Systolic blood pressure, DBP Diastolic blood pressure, TC Total cholesterol, TG Triglycerides, HDL-c HDL-cholesterol, CRP C-reactive protein, IL-6 Interleukin-6, NLR Neutrophil-to-lymphocyte ratio, PLR Platelet-to-lymphocyte ratio, sICAM-1 Soluble intercellular adhesion molecule-1. Results are expressed as the mean ± S.E.M