Table 1 First questionnaire^a administered to the Board

1

Would you use the fixed combination for the treatment of postoperative pain?

Yes/No

If so, in which cases? If not, why? (Open field)

2

The fixed combination in the pediatric setting is effective in case of:

Select one or more options:

Headaches

Rheumatic pain

Earache

Post-traumatic musculoskeletal pain

Odontalgia

Other (open field)

3

The fixed combination in the pediatric setting is ineffective in case of:

Select one or more options:

Headaches

Rheumatic pain

Earache

Post-traumatic musculoskeletal pain

Odontalgia

Other (open field)

4

In the pediatric field, the oral suspension of the fixed combination would be preferred because:

Select one or more options:

It allows a simple and accurate definition of the dose as a function of body weight

It guarantees a homogeneous trend with the variation of the weight of the child and uniformity in the frequency of administration

It allows to minimize the variability between dosages in terms of mg/kg of the active ingredients administered

It guarantees greater regularity and completeness of the absorption of the active ingredient

Other (open field)

5

What are the factors that could make the fixed combination effective?

Select one or more options:

Complementarity of the mechanisms of action

Synergy between the effects of the two substances

Reduction of the dosage of ibuprofen

Reduction of the maximum daily dose of each drug

Increased time interval between drug administration

Reduction of the risk of incorrect administration of individual active ingredients

Other (open field)

6

What do you think are the possible implications in terms of safety and tolerability of the fixed combination?

Select one or more options:

Safety especially in patients with comorbidities or in polytherapy

Superior analgesia compared to single drugs used alone without compromising tolerability

Increased risk of gastrointestinal side effects

Increased risk of hepatic side effects

Other (open field)

7

What do you think is the pharmacodynamic advantage of the fixed combination?

Select one of the options:

Greater analgesic power

Greater anti-inflammatory power

Both of them

Neither

8

In case of ineffectiveness of paracetamol alone, would you use the fixed combination?

Yes/No

If so, in which cases? If not, why? (Open field)

9

In case of ineffectiveness of ibuprofen alone, would you use the fixed combination?

Yes/No

If so, in which cases? If not, why? (Open field)

10

Would you use the combination for the treatment of discomfort (defined as mild or moderate acute pain)?

Yes/No

If so, in which cases? If not, why? (Open field)