Table 3 Questions approved at final meeting and clinician' responses
N | Question | Option answers validated at the second questionnair | Clinician’ answers (n = 10) | Approved at final meeting |
|---|---|---|---|---|
1 | Would you use the fixed combination for the treatment of postoperative pain? | Option Yes (validated at the first round) | 9 | Confirmed consensus at the final meeting |
2 | Derived from the open field of the first round In which cases would you use the fixed combination for the treatment of postoperative pain (having assessed the antiplatelet effect of ibuprofen in order not to compromise hemostasis)? | When both anti-inflammatory and analgesic effects are desired (validated at the first round) | 8 | Confirmed consensus at the final meeting |
When paracetamol alone does not control pain | 6 | Agreed consensus following brainstorming | ||
3 | The fixed combination in the pediatric setting is effective in case of: | Odontalgia (validated at the first round) | 10 | Confirmed consensus at the final meeting |
Headaches (validated at the first round) | 9 | Confirmed consensus at the final meeting | ||
Earache (validated at the first round) | 8 | Confirmed consensus at the final meeting | ||
Musculoskeletal pain (validated at the first round) | 8 | Confirmed consensus at the final meeting | ||
Chronic rheumatic pain (option derived from the open field of first round) | 8 | Confirmed consensus at the final meeting | ||
4 | Reintroduced with rewording of the answer options based on first round results In the pediatric field, the oral suspension of the fixed combination would be preferred because: | It optimizes the dosage in relation to the weight of the child (reworded from the first round) | 7 | Confirmed consensus at the final meeting |
It reduces parental dosing errors compared to the combined administration of two separate drugs (derived from the open field of first round) | 9 | Confirmed consensus at the final meeting | ||
It allows for quick pain control with greater effectiveness (derived from the open field of first round) | 5 | Agreed consensus following brainstorming | ||
5 | What are the factors that could make the fixed combination effective? | Complementarity of the mechanisms of action (validated at the first round) | 9 | Confirmed consensus at the final meeting |
Synergy between the effects of the two substances (validated at the first round) | 7 | Confirmed consensus at the final meeting | ||
6 | What do you think are the possible implications in terms of safety and tolerability of the fixed combination? | Superior analgesia compared to single drugs used alone without compromising tolerability (validated at the first round) | 9 | Confirmed consensus at the final meeting |
7 | Reintroduced for intermediate agreement of the first round What do you think is the pharmacodynamic advantage of the fixed combination? | Greater analgesic power | 8 | Confirmed consensus at the final meeting |
8 | In case of inefficacy of paracetamol alone, would you use the fixed combination? | Option Yes (validated at the first round) | 8 | Confirmed consensus at the final meeting |
9 | Derived from the open field of first round In case of inefficacy of paracetamol alone, would you use the fixed combination? | Headaches | 5 | Agreed consensus to all options at the last meetinga |
Earache | 6 | |||
Post-traumatic musculoskeletal pain | 9 | |||
Odontalgia | 7 | |||
Moderate pain that does not respond to the administration of ibuprofen alone in the first instance | 8 | Confirmed consensus at the final meeting | ||
10 | --In case of inefficacy of ibuprofen alone, would you use the fixed combination? | Option Yes (validated at the first round) | 8 | Confirmed consensus at the final meeting |
11 | Derived from the open field of first round In case of inefficacy f ibuprofen alone, would you use the fixed combination? | Headaches | 7 | Agreed consensus to all options at the last meetinga |
Chronic rheumatic painb | 5 | |||
Post-traumatic musculoskeletal pain | 8 | |||
Odontalgia | 8 | |||
Moderate pain that does not respond to the administration of paracetamol alone in the first instance | 7 | Confirmed consensus at the final meeting | ||
12 | --Would you use the fixed combination for acute pain treatment?c | Moderate (4–6 score) | 7 | Confirmed consensus at the final meeting |