From: Citicoline in hypoxic ischemic encephalopathy in neonates: a randomized controlled trial
Parameters | Citicoline group | Control group | P |
---|---|---|---|
GA (weeks) | 38.3 ± 1.8 | 38.1 ± 1.7 | 0.658 |
Birth Weight (gm) | 2990 ± 670 | 2850 ± 590 | 0.331 |
Sex (male:female) | 20:20 | 27:13 | 0.112 |
Duration of resuscitation (min) | 11 (6–20) | 9 (5–19) | 0.068 |
Apgare score at 10 min | 3.58 ± 1.26 | 3.60 ± 1.32 | 0.889 |
PH (first hour) | 6.98 ± 0.11 | 7.01 ± 0.10 | 0.305 |
HCO3 | 12 (2–19) | 12.5 (2–20) | 0.012 |
Base deficit | 16.13 ± 1.04 | 16 ± 0.93 | 0.679 |
Urinary Lactate/creatine ratio | 0.79 ± 0.09 | 0.80 ± 0.09 | 0.468 |
Sarnat staging: N (%) | |||
-stage 2 | 19 (47.5%) | 23 (57.5%) | 0.370 |
-stage 3 | 21 (52.5%) | 17(42.5%) | |
EEG: N (%) | |||
-Normal continuous | 22 (55%) | 28 (70%) | 0.554 |
-Low voltage | 5 (12.5%) | 2 (5%) | |
-Burst suppression | 5 (12.5%) | 4 (10%) | |
-Seizure activity | 7 (17.5%) | 4 (10%) | |
-Paroxysmal generalized epileptiform | 1 (2.5%) | 2 (5%) |