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Table 1 Characteristics of included studies

From: The efficacy and safety of fluconazole in preventing invasive fungal infection in very low birth weight infants: a systematic review and meta-analysis

Authors

Year

Patients

(control/ experimental)

Birth weight (control/ experimental, g)

Dose of fluconazole

Administration of therapy

Outcomes

Kicklighter et al. [7]

2001

50/53

919 ± 239/ 992 ± 258

6 mg/kg, every third day for 1 week then daily

Intravenous injection

a,b,c,

Kaufman et al. [8]

2001

50/50

744 ± 157/ 717 ± 150

3 mg/kg, every third day for two weeks; every 48 h for 2 weeks and then daily

Intravenous injection

a,b,c,

Parikh et al. [9]

2007

60/60

1280 ± 199/1210 ± 241

6 mg/kg, every 72 h till day 7 and subsequently every 24 h

Intravenous injection

a,b

Aydemir et al. [10]

2011

91/93

1102 ± 238/1127 ± 215

3 mg/kg, every third day

Intravenous injection

a,b,c,d

Manzoni et al. [11]

2007

106/216

1120 ± 270/1060 ± 245

112 patients received 6 mg/kg, 104 patients received 3 mg/kg, every third day for two weeks, then every 48 h

Intravenous injection

a,b,c,d

Aghai et al. [12]

2006

137/140

681 ± 169/749 ± 133

3 mg/kg, every 72 h for 2 weeks; every 48 h 2 weeks and daily 2 weeks

Intravenous injection

a,c

Benjamin et al. [13]

2014

173/188

640(573–700)/653(570–700)

6 mg/kg, twice weekly

Intravenous injection

a,c

Jannatdoust et al. [14]

2015

50/43

976 ± 203/969 ± 163

3 mg/kg, every 72 h till day 7 and subsequently every 24 h

Intravenous injection

c

Kirpal et al. [15]

2016

37/38

1220 ± 130/1250 ± 360

6 mg/kg, every 72 h till day 7 and subsequently every 24 h

Intravenous injection

a,c,d

  1. a: Incidence of IFI; b: Fungal colonization rate; c: In-hospital mortality; d: Fungal infection-related mortality